A chain collision involving three vehicles on the B2 road near Usakos claimed the life of one person on Friday.
Chief Inspector Jatikua Tjiramba also confirmed that the driver of a car that left the road between Okahandja and Karibib on Saturday is in a critical condition.
In the three-car pile-up James Ngoshi (38) died on the spot.
The passengers of the two other vehicles sustained minor to serious injuries and were taken to the Usakos and Swakopmund state hospitals.
Detective Chief Inspector Erastus Iikuyu said a Toyota Etios with a Walvis Bay registration, driven by Ngoshi, overtook a white Kia about 54km from Usakos. He swerved off the road to avoid hitting a car approaching from the opposite direction.
When Ngoshi swerved back onto the road he smashed head-on into an oncoming Ford Ranger bakkie carrying Michael Kasheeta (50) and an 11-year-old boy who was rushed to a Windhoek hospital.
The Kia driven by Hilga Daveres (42), accompanied by her son Sandro Daveres (18), crashed into the back of the Etios.
The same road claimed the lives of two schoolgirls and the driver of a bakkie that overturned last week.
Statistics provided by the Motor Vehicle Accident (MVA) Fund show that 492 persons died in 2 932 car crashes between January and 18 September.
Meanwhile, on the Ondangwa-Oshikango main road at the Onhuno T-junction a pedestrian identified as eight-year-old Alfeus Johannes died after he was hit by a silver Volkswagen Golf.
It is alleged that the boy was among a group of children who crossed the road. Johannes hesitated and when he finally crossed the road he was hit and died on the spot.